AFPep
AFPep is a synthetic peptide that has been developed as a potential therapeutic agent for the treatment of breast cancer. It is derived from the alpha-fetoprotein (AFP), a protein that is produced in the liver of a developing fetus. AFPep has been shown to inhibit the growth of breast cancer cells in laboratory studies.
Structure and Function[edit | edit source]
AFPep is a small peptide, consisting of only 9 amino acids. It is derived from a specific region of the alpha-fetoprotein molecule, known as the "growth inhibitory domain". This region of the AFP molecule has been shown to have the ability to inhibit the growth of breast cancer cells.
The exact mechanism by which AFPep exerts its anti-cancer effects is not fully understood. However, it is believed to work by binding to the estrogen receptor on the surface of breast cancer cells, thereby blocking the effects of estrogen, a hormone that can stimulate the growth of breast cancer cells.
Clinical Studies[edit | edit source]
Several preclinical studies have been conducted to evaluate the potential of AFPep as a treatment for breast cancer. These studies have shown that AFPep can inhibit the growth of breast cancer cells in vitro (in a laboratory dish) and in vivo (in animals).
Clinical trials are currently underway to further evaluate the safety and efficacy of AFPep in patients with breast cancer. These trials are being conducted by AFPep Therapeutics, a biotechnology company that is developing AFPep as a novel therapeutic agent for the treatment of breast cancer.
Potential Applications[edit | edit source]
In addition to its potential use as a treatment for breast cancer, AFPep may also have applications in the prevention of breast cancer. Studies have shown that AFPep can inhibit the growth of breast cancer cells that are resistant to tamoxifen, a drug that is commonly used in the prevention and treatment of breast cancer. This suggests that AFPep may be a useful therapeutic agent in patients who are resistant to tamoxifen.
See Also[edit | edit source]
References[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
