ALK6

ALK6 or Activin receptor-like kinase 6 is a type of protein that in humans is encoded by the BMPR1B gene. It is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases.

Function

The function of ALK6 is primarily associated with the BMP pathway, a signaling pathway that plays a crucial role in the development and regulation of the cellular and physiological processes in the body. The BMP pathway is involved in various cellular processes, including cell growth, differentiation, and apoptosis.

ALK6, as a BMP receptor, binds to BMP ligands to initiate the BMP signaling pathway. This binding leads to the phosphorylation and activation of SMAD proteins, which then regulate the transcription of target genes in the nucleus.

Clinical Significance

Mutations in the BMPR1B gene, which encodes ALK6, have been associated with primary pulmonary hypertension and juvenile polyposis syndrome. Further research is needed to fully understand the role of ALK6 in these conditions and to develop potential therapeutic strategies.

See Also

• Bone morphogenetic protein
• SMAD
• Transmembrane protein
• Serine/threonine-specific protein kinase

References

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