AM-251
AM-251 is a drug that acts as a selective antagonist at the cannabinoid receptor CB1, and is used in scientific research. It is structurally related to the more well-known compound SR141716A, which is approximately equivalent in potency, but AM-251 is slightly more selective for CB1, versus the CB2 subtype, with a Ki of 7.49nM at CB1 vs 403nM at CB2.
Pharmacology[edit | edit source]
AM-251 is a selective antagonist at the cannabinoid receptor CB1. It is used in scientific research to explore the role of the endocannabinoid system in the body. The compound is structurally related to SR141716A, another cannabinoid receptor antagonist. However, AM-251 is slightly more selective for the CB1 receptor subtype, with a Ki of 7.49nM at CB1 and 403nM at CB2.
Chemistry[edit | edit source]
AM-251 is a derivative of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide. It is a white crystalline solid that is soluble in organic solvents.
Uses[edit | edit source]
AM-251 is primarily used in scientific research. It is used to study the role of the endocannabinoid system in various physiological processes, including pain sensation, mood regulation, and appetite control. It is also used to investigate the potential therapeutic applications of CB1 receptor antagonists.
See also[edit | edit source]
References[edit | edit source]
| AM-251 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
