AM-678

AM-678 is a synthetic cannabinoid that acts as a potent agonist for the cannabinoid receptors. It was first identified in Japan in 2012. Although it was developed for medicinal use, it has been sold as a designer drug.

Chemistry

AM-678 is a derivative of cannabidiol, a cannabinoid found in cannabis. It is a full agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.45 nM at CB1 and 0.69 nM at CB2. This makes it significantly more potent than natural cannabinoids such as THC, which is a partial agonist at these receptors.

Pharmacology

The pharmacological effects of AM-678 are similar to those of other cannabinoids. It produces feelings of euphoria, relaxation, and altered perception. However, it also has a number of side effects, including anxiety, paranoia, and psychosis. These effects are thought to be due to its high potency and full agonist activity at the CB1 receptor.

Legal Status

AM-678 is illegal in many countries, including the United States, the United Kingdom, and Japan. It is often sold as a "legal high" or "research chemical", but these sales are usually illegal. In the United States, it is classified as a Schedule I controlled substance, which means it has a high potential for abuse and no accepted medical use.

See Also

• Cannabinoid
• Cannabidiol
• THC
• Designer drug
• Cannabinoid receptors

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