APOBEC4
APOBEC4 (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 4) is a protein that in humans is encoded by the APOBEC4 gene. It is a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of proteins.
Function[edit | edit source]
APOBEC4, like other members of the APOBEC family, is thought to play a role in the immune system. However, the specific function of APOBEC4 is not well understood. It is known to be expressed in the testis and brain, suggesting a role in these tissues.
Structure[edit | edit source]
The APOBEC4 protein is 349 amino acids in length. It contains a single zinc-coordinating domain, which is characteristic of the APOBEC family. This domain is thought to be involved in the catalytic activity of the protein.
Clinical significance[edit | edit source]
While the function of APOBEC4 is not well understood, mutations in this gene have been associated with a variety of diseases. For example, a mutation in APOBEC4 has been linked to Alzheimer's disease. More research is needed to fully understand the role of APOBEC4 in human health and disease.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
