APOBEC4

APOBEC4 (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 4) is a protein that in humans is encoded by the APOBEC4 gene. It is a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of proteins.

Function

APOBEC4, like other members of the APOBEC family, is thought to play a role in the immune system. However, the specific function of APOBEC4 is not well understood. It is known to be expressed in the testis and brain, suggesting a role in these tissues.

Structure

The APOBEC4 protein is 349 amino acids in length. It contains a single zinc-coordinating domain, which is characteristic of the APOBEC family. This domain is thought to be involved in the catalytic activity of the protein.

Clinical significance

While the function of APOBEC4 is not well understood, mutations in this gene have been associated with a variety of diseases. For example, a mutation in APOBEC4 has been linked to Alzheimer's disease. More research is needed to fully understand the role of APOBEC4 in human health and disease.

See also

• APOBEC
• Alzheimer's disease

References

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