ARHGAP27

ARHGAP27 is a gene that in humans encodes the protein known as Rho GTPase activating protein 27. This protein is a member of the Rho GTPase family, which are key regulators of the actin cytoskeleton and cellular polarity.

The structure of the ARHGAP27 protein.

Function

The ARHGAP27 protein is involved in the regulation of cell adhesion and cell migration. It acts by inhibiting the activity of Rho GTPases, which are involved in the regulation of the actin cytoskeleton. This inhibition is achieved by promoting the hydrolysis of GTP to GDP, thereby inactivating the GTPase.

Clinical significance

Mutations in the ARHGAP27 gene have been associated with a variety of diseases, including cancer, cardiovascular disease, and neurological disorders. In particular, it has been suggested that alterations in the function of ARHGAP27 may contribute to the development of glioblastoma, a type of brain cancer.

Research

Research into the function and role of ARHGAP27 in disease is ongoing. Current areas of focus include understanding the molecular mechanisms by which ARHGAP27 regulates cell adhesion and migration, and investigating the potential role of ARHGAP27 in the development and progression of cancer.

See also

• Rho GTPase
• Cell adhesion
• Cell migration
• Glioblastoma