ASIC4

ASIC4 or Acid Sensing Ion Channel Subunit Family Member 4 is a protein that in humans is encoded by the ASIC4 gene. It is a member of the acid-sensing ion channels (ASICs) family, which are part of the Degenerin/Epithelial Sodium Channel (DEG/ENaC) superfamily of ion channels.

Function

ASIC4 is a member of a class of proteins that form ion channels sensitive to protons, which are found in sensory neurons. These channels are thought to be involved in the pain perception and pH homeostasis. ASIC4, unlike other members of its family, is insensitive to amiloride and can function in a homo- or heteromeric with other ASIC proteins.

Structure

The ASIC4 protein is composed of about 512 amino acids and has two transmembrane domains. The large extracellular loop contains the proton sensor and is responsible for the channel's sensitivity to pH. The intracellular N and C termini are involved in the regulation of the channel's activity.

Clinical significance

While the exact role of ASIC4 in human health and disease is not fully understood, it is thought to play a role in the perception of pain and possibly in the development of certain neurological disorders. Studies have suggested that ASIC4 may be involved in the pathogenesis of Parkinson's disease and Alzheimer's disease, although more research is needed to confirm these findings.

See also

• Acid-sensing ion channels
• Degenerin/Epithelial Sodium Channel