ASK1
ASK1 (Apoptosis signal-regulating kinase 1) is a protein that in humans is encoded by the MAP3K5 gene. ASK1 is a member of the MAP kinase kinase kinase (MAP3K) family, which plays a key role in the induction of apoptosis.
Function[edit | edit source]
ASK1 is activated by various molecular events such as oxidative stress, and upon activation, ASK1 activates the JNK and p38 MAP kinase pathways by phosphorylating and activating several MAP kinase kinases, which in turn activate the MAP kinases. The activation of ASK1 leads to the activation of a signaling cascade that culminates in apoptosis.
Clinical significance[edit | edit source]
Alterations in the ASK1 signaling pathway have been implicated in a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. In cancer, ASK1 has been shown to be a tumor suppressor, and its loss of function is associated with tumor progression. In neurodegenerative diseases, ASK1 activation has been linked to neuronal cell death. In cardiovascular diseases, ASK1 activation is associated with cardiac hypertrophy and heart failure.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- MAP3K5 gene at NCBI
- ASK1 protein at UniProt
ASK1 Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD