ATG9B

ATG9B is a protein that in humans is encoded by the ATG9B gene. Autophagy is a process of intracellular bulk degradation in which cytoplasmic components, including organelles, are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. ATG9B plays an important role in this process.

Function

Autophagy is a process that occurs in response to nutrient starvation and metabolic stress where the cell self-digests its own components. ATG9B is an essential component of the autophagy pathway. It is involved in the formation of autophagosomes, the double-membrane vesicles that sequester cytoplasmic material for degradation in the lysosome.

ATG9B is a transmembrane protein that cycles between the Golgi apparatus, endosomes, and autophagosomes. It is thought to function in the delivery of membrane to growing autophagosomes.

Clinical significance

Alterations in the autophagy pathway have been associated with a variety of human diseases, including cancer, neurodegenerative diseases, and infections. As a key component of the autophagy pathway, ATG9B may play a role in these diseases.

See also

• Autophagy
• ATG9A
• Lysosome

External links

• ATG9B at the National Center for Biotechnology Information