ATOX1

ATOX1 (Antioxidant protein 1) is a protein that in humans is encoded by the ATOX1 gene. It is a copper chaperone that plays a significant role in the human body's copper homeostasis.

Function

ATOX1 is a copper chaperone, transporting copper to the ATP7A and ATP7B proteins in the trans-Golgi network. This protein also has an antioxidant activity against superoxide and hydroxyl radicals, and may play a significant role in cancer progression.

Clinical significance

Mutations in the ATOX1 gene have been associated with diseases such as Menkes disease and Wilson's disease, which are caused by defects in copper transport. Recent studies have also suggested a potential role of ATOX1 in cancer progression.

Interactions

ATOX1 has been shown to interact with ATP7B and ATP7A.

See also

• Copper in health
• Menkes disease
• Wilson's disease

External links

• Human ATOX1 gene details page in the NCBI database
• Human ATOX1 protein details page in the NCBI database

ATOX1 Resources
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