AVN-101
AVN-101 is a novel, orally bioavailable, low toxic, multi-target drug that has a strong anxiolytic, antidepressant, neuroprotective, and anti-inflammatory effects. It is a third-generation antipsychotic drug that is currently in the clinical trial phase.
Mechanism of Action[edit | edit source]
AVN-101 acts on several receptors in the brain, including serotonin receptors, adrenergic receptors, and histamine receptors. It has a high affinity for the 5-HT7 and 5-HT6 receptors, moderate affinity for the 5-HT2A, 5-HT2C, and 5-HT1A receptors, and low affinity for the 5-HT3 receptor. AVN-101 also has a high affinity for the α2C-adrenergic receptor and the H1 histamine receptor.
Clinical Trials[edit | edit source]
AVN-101 has undergone Phase I and Phase IIa clinical trials for the treatment of cognitive impairment in schizophrenia and Alzheimer's disease. The results of these trials have shown that AVN-101 is safe and well-tolerated, with no serious adverse events reported. The drug has also shown promising results in improving cognitive function in patients with schizophrenia and Alzheimer's disease.
Potential Applications[edit | edit source]
In addition to its potential use in treating cognitive impairment in schizophrenia and Alzheimer's disease, AVN-101 may also have potential applications in the treatment of anxiety disorders, depression, post-traumatic stress disorder (PTSD), and sleep disorders. Further research is needed to confirm these potential applications.
See Also[edit | edit source]
- Antipsychotic
- Serotonin receptor
- Adrenergic receptor
- Histamine receptor
- Schizophrenia
- Alzheimer's disease
- Anxiety disorders
- Depression
- Post-traumatic stress disorder
- Sleep disorders
References[edit | edit source]
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