AZGP1
AZGP1[edit | edit source]
AZGP1 (Alpha-2-glycoprotein 1, zinc-binding) is a protein that in humans is encoded by the AZGP1 gene. This protein is a member of the zinc-alpha-2-glycoprotein family and is involved in various biological processes, including lipid metabolism and immune response.
Structure[edit | edit source]
AZGP1 is a soluble protein that is secreted by various tissues, including the liver and adipose tissue. It is composed of a single polypeptide chain and has a molecular weight of approximately 41 kDa. The protein structure includes a zinc-binding domain, which is crucial for its function.
Function[edit | edit source]
AZGP1 is known to play a role in lipid mobilization and metabolism. It acts as a lipid-mobilizing factor, promoting the breakdown of lipids in adipose tissue. This function is particularly important in the context of cachexia, a condition characterized by severe weight loss and muscle wasting, often seen in cancer patients.
Additionally, AZGP1 has been implicated in the regulation of immune responses. It is thought to modulate the activity of natural killer cells and T cells, contributing to the body's defense mechanisms against infections and malignancies.
Clinical Significance[edit | edit source]
The expression levels of AZGP1 have been studied in various cancers, including prostate cancer, breast cancer, and lung cancer. In some cases, elevated levels of AZGP1 are associated with a better prognosis, while in others, they may indicate a more aggressive disease.
Research has also suggested that AZGP1 could serve as a potential biomarker for certain diseases, aiding in diagnosis and monitoring of treatment responses.
Research[edit | edit source]
Ongoing research is focused on understanding the precise mechanisms by which AZGP1 influences lipid metabolism and immune function. Studies are also exploring its potential as a therapeutic target in metabolic disorders and cancer.
Also see[edit | edit source]
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Resources[edit source]
Latest articles - AZGP1
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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on AZGP1 for any updates.
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