Abnormal liver function tests

Abnormal liver function tests (LFTs) are a group of blood tests used to assess the state of the liver and biliary system. The liver performs a variety of essential tasks ranging from producing proteins, cholesterol, and bile to storing vitamins, minerals, and even carbohydrates. It also plays a significant role in breaking down toxins like alcohol, medications, and natural byproducts of metabolism. Keeping the liver in good health is crucial for maintaining overall well-being.

Overview

Abnormal liver function tests can indicate the presence of liver disease or damage. These tests measure levels of various enzymes and proteins in the blood, including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, and albumin. Elevated or decreased levels of these substances can signal liver abnormalities that may require further investigation.

Types of Tests

• Alanine transaminase (ALT): An enzyme found mainly in the liver. High levels of ALT in the blood can indicate liver damage.
• Aspartate transaminase (AST): An enzyme found in various parts of the body, including the liver. Elevated AST levels can also suggest liver damage but are not as specific to the liver as ALT.
• Alkaline phosphatase (ALP): An enzyme related to the bile ducts; high levels can indicate bile duct obstruction or liver damage.
• Bilirubin: A substance produced during the normal breakdown of red blood cells. High levels can lead to jaundice and indicate liver or bile duct problems.
• Albumin: The main protein made by the liver; low levels can suggest liver damage or disease.

Causes of Abnormal LFTs

Abnormal liver function tests can result from a variety of conditions, including but not limited to:

• Hepatitis (inflammation of the liver due to viral infections, toxic substances, or autoimmune diseases)
• Fatty liver disease (accumulation of fat in the liver cells)
• Cirrhosis (scarring of the liver tissue)
• Alcohol-related liver disease
• Bile duct obstruction
• Liver cancer
• Medications that can damage the liver

Symptoms of Liver Disease

While abnormal LFTs can be an early sign of liver disease, many individuals with liver problems do not experience symptoms until the disease has progressed. When symptoms do occur, they may include:

• Jaundice (yellowing of the skin and eyes)
• Abdominal pain and swelling
• Swelling in the legs and ankles
• Itchy skin
• Dark urine color
• Pale stool color
• Chronic fatigue
• Nausea or vomiting

Diagnosis and Treatment

If liver function tests are abnormal, further testing is often necessary to determine the underlying cause. This may include imaging tests like ultrasound, CT scan, or MRI, and sometimes a liver biopsy. Treatment for liver disease depends on the diagnosis and may involve lifestyle changes, medication, or in severe cases, surgery or liver transplantation.

Prevention

Preventing liver disease involves maintaining a healthy lifestyle, including avoiding excessive alcohol consumption, managing weight, and avoiding risky behaviors that can lead to viral hepatitis. Regular monitoring and early detection through liver function tests can also play a crucial role in managing liver health.