Acefylline

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Acefylline

Acefylline (also known as acetyloxyethyltheophylline or acetyloxyethyltheobromine) is a pharmacological agent that belongs to the class of xanthine derivatives. It is primarily used as a bronchodilator in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Pharmacology

Acefylline is a theophylline derivative, which means it is structurally related to the naturally occurring xanthine alkaloids caffeine, theobromine, and theophylline. It acts as a non-selective adenosine receptor antagonist and phosphodiesterase inhibitor, leading to an increase in intracellular cAMP, relaxation of smooth muscles, and hence bronchodilation.

Clinical Use

Acefylline is used in the treatment of respiratory diseases characterized by constriction of airways, such as asthma and chronic obstructive pulmonary disease (COPD). It helps to relax and open air passages in the lungs, making it easier to breathe.

Side Effects

Like other xanthine derivatives, acefylline can cause a range of side effects. These can include nausea, vomiting, abdominal pain, and diarrhea. More serious side effects can include arrhythmia and seizures, particularly at high doses or in patients with certain risk factors.

Contraindications

Acefylline is contraindicated in patients with a history of hypersensitivity to xanthine derivatives. It should also be used with caution in patients with peptic ulcer disease, seizure disorders, and certain heart conditions.

See Also

• Theophylline
• Xanthine
• Bronchodilator
• Asthma
• Chronic obstructive pulmonary disease