Acid-sensing ion channel
Acid-sensing ion channels (ASICs) are a family of ion channels that are activated by low extracellular pH. They belong to the DEG/ENaC superfamily of ion channels and are widely expressed in the nervous system, where they contribute to the sensation of pain, taste, and fear.
Structure[edit | edit source]
ASICs are composed of subunits, each of which has two transmembrane domains, a large extracellular loop, and short intracellular N and C termini. The channels are thought to assemble as trimers, with each subunit contributing to the formation of the ion pore.
Function[edit | edit source]
ASICs are activated by a decrease in extracellular pH, a condition that can occur during ischemia, inflammation, and in certain tumours. Upon activation, they allow the passage of Na+ ions into the cell, which can trigger a variety of cellular responses, including neuronal excitability, gene expression, and cell death.
Clinical significance[edit | edit source]
Due to their role in pain sensation and neuronal damage, ASICs are considered potential targets for the treatment of a variety of conditions, including neuropathic pain, ischemic brain injury, and certain types of cancer.
See also[edit | edit source]
References[edit | edit source]
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