Acyl-CoA thioesterase 9

Acyl-CoA thioesterase 9 (ACOT9) is an enzyme that in humans is encoded by the ACOT9 gene. This enzyme is part of the Acyl-CoA thioesterase family, which is involved in the breakdown of fatty acids.

Function

ACOT9 is an enzyme that catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoA), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoA. It has been suggested that this enzyme may have a role in lipid metabolism and the maintenance of cell membrane integrity.

Structure

The ACOT9 gene is located on the X chromosome (specifically, Xq26.3). The protein encoded by this gene is a peroxisomal enzyme that catalyzes the conversion of acyl-CoAs to free fatty acids and CoA.

Clinical significance

Mutations in the ACOT9 gene have been associated with X-linked intellectual disability. Further research is needed to fully understand the role of this enzyme in human health and disease.

See also

• Acyl-CoA thioesterase
• Fatty acid metabolism
• X-linked intellectual disability

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.