Acyl-CoA thioesterase 9
Acyl-CoA thioesterase 9 (ACOT9) is an enzyme that in humans is encoded by the ACOT9 gene. This enzyme is part of the Acyl-CoA thioesterase family, which is involved in the breakdown of fatty acids.
Function[edit | edit source]
ACOT9 is an enzyme that catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoA), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoA. It has been suggested that this enzyme may have a role in lipid metabolism and the maintenance of cell membrane integrity.
Structure[edit | edit source]
The ACOT9 gene is located on the X chromosome (specifically, Xq26.3). The protein encoded by this gene is a peroxisomal enzyme that catalyzes the conversion of acyl-CoAs to free fatty acids and CoA.
Clinical significance[edit | edit source]
Mutations in the ACOT9 gene have been associated with X-linked intellectual disability. Further research is needed to fully understand the role of this enzyme in human health and disease.
See also[edit | edit source]
References[edit | edit source]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Contributors: Prab R. Tumpati, MD