Adapalene/benzoyl peroxide
Adapalene/benzoyl peroxide
Adapalene/benzoyl peroxide is a combination medication used in the treatment of acne vulgaris. It combines two active ingredients: adapalene, a retinoid, and benzoyl peroxide, an antimicrobial and keratolytic agent. This combination is effective in reducing inflammation, comedones, and bacterial growth associated with acne.
Mechanism of Action[edit | edit source]
Adapalene is a third-generation retinoid that modulates cellular differentiation, keratinization, and inflammatory processes. It binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. This action helps to normalize the differentiation of follicular epithelial cells, resulting in decreased microcomedone formation.
Benzoyl peroxide works by releasing free radical oxygen species that oxidize bacterial proteins, particularly in Propionibacterium acnes, the bacteria involved in acne. It also has keratolytic effects, helping to clear blocked pores and reduce sebaceous gland activity.
Clinical Use[edit | edit source]
Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris in patients aged 12 years and older. It is applied once daily to affected areas after washing. The combination is particularly useful for patients with inflammatory and non-inflammatory acne lesions.
Side Effects[edit | edit source]
Common side effects include skin irritation, dryness, erythema, and peeling. These effects are usually mild to moderate and tend to decrease with continued use. Patients are advised to use a moisturizer and to avoid excessive sun exposure or use of other potentially irritating topical products.
Precautions[edit | edit source]
Patients should be advised to avoid contact with the eyes, lips, and mucous membranes. Adapalene/benzoyl peroxide should not be applied to cuts, abrasions, or eczematous skin. Caution is advised in patients with a history of hypersensitivity to any of the components.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
