Adenomyoepithelioma of the breast

Adenomyoepithelioma of the Breast

Adenomyoepithelioma of the breast is a rare breast tumor characterized by the proliferation of both epithelial and myoepithelial cells. This type of tumor can present in various forms and may exhibit benign or malignant behavior.

Pathology

Adenomyoepitheliomas are composed of two distinct cell types: epithelial cells and myoepithelial cells. The epithelial component typically forms glandular structures, while the myoepithelial component surrounds these structures and can appear spindle-shaped or clear.

Histological Features

Under the microscope, adenomyoepitheliomas can show a range of appearances depending on the proportion and arrangement of the epithelial and myoepithelial cells. The tumors can be well-circumscribed or infiltrative. The myoepithelial cells may show clear, eosinophilic, or spindle-shaped cytoplasm.

Clinical Presentation

Patients with adenomyoepithelioma of the breast may present with a palpable mass. The tumor is often detected during routine mammography or breast ultrasound. It can occur in women of any age but is most commonly found in middle-aged and older women.

Diagnosis

The diagnosis of adenomyoepithelioma is primarily based on histological examination. Immunohistochemistry can be used to confirm the presence of myoepithelial cells, which typically express markers such as p63, smooth muscle actin, and calponin.

Treatment

The treatment of adenomyoepithelioma depends on its behavior. Benign tumors may be managed with surgical excision, while malignant or recurrent tumors may require more extensive surgery and possibly radiation therapy.

Prognosis

The prognosis for patients with adenomyoepithelioma of the breast is generally good, especially for benign tumors. However, malignant adenomyoepitheliomas can metastasize and require more aggressive treatment.

Related Pages

• Breast cancer
• Myoepithelial cell
• Histopathology
• Immunohistochemistry

Gallery

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  Very high magnification of adenomyoepithelioma

• Low magnification of adenomyoepithelioma

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  High magnification of adenomyoepithelioma

Adenomyoepithelioma of the breast

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  Adenomyoepithelioma - very high magnification

• Adenomyoepithelioma - low magnification

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  Adenomyoepithelioma - high magnification