Adnexus
Adnexus Adnexus, a biotechnology company, is known for its pioneering work in the development of therapeutic proteins and biopharmaceuticals. The company was founded in 2003 and is headquartered in Waltham, Massachusetts. Adnexus is a subsidiary of Bristol-Myers Squibb, a global biopharmaceutical company.
History[edit | edit source]
Adnexus was originally established as Adnexus Therapeutics. The company focused on the development of a new class of therapeutic proteins known as Adnectins. In 2007, Adnexus was acquired by Bristol-Myers Squibb for $430 million, which allowed the company to leverage Bristol-Myers Squibb's resources and expertise in drug development and commercialization.
Technology[edit | edit source]
Adnexus is renowned for its proprietary technology platform, which is based on Adnectins. Adnectins are engineered proteins derived from the 10th type III domain of human fibronectin. These proteins can be designed to bind to specific targets with high affinity and specificity, making them useful in a variety of therapeutic applications.
Adnectins[edit | edit source]
Adnectins are a class of engineered proteins that have been optimized for therapeutic use. They are designed to bind to specific molecular targets, such as receptors or enzymes, with high affinity. This binding can modulate the activity of the target, providing a therapeutic effect. Adnectins are structurally similar to antibodies but are smaller and can be engineered to have improved stability and pharmacokinetic properties.
Research and Development[edit | edit source]
Adnexus has focused its research and development efforts on creating Adnectins for the treatment of various diseases, including cancer, inflammatory diseases, and cardiovascular diseases. The company's lead product candidates have shown promise in preclinical and clinical studies, demonstrating the potential of Adnectins as a new class of therapeutics.
Partnerships and Collaborations[edit | edit source]
Adnexus has established several partnerships and collaborations with other biotechnology and pharmaceutical companies to advance the development of its Adnectin-based therapies. These collaborations have provided Adnexus with access to additional resources and expertise, accelerating the development and commercialization of its product candidates.
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References[edit | edit source]
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