Adosterol

A radiolabeled cholesterol analog used in medical imaging

Adosterol
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Adosterol is a radiolabeled cholesterol analog used primarily in medical imaging to assess adrenal gland function. It is particularly useful in the diagnosis of adrenal gland disorders such as Conn's syndrome and Cushing's syndrome.

Chemical structure

Adosterol is a synthetic derivative of cholesterol, specifically designed to mimic the behavior of cholesterol in the body while being detectable through imaging techniques. The compound is labeled with the radioactive isotope iodine-131, which allows for its detection using scintigraphy.

Mechanism of action

Adosterol works by being selectively taken up by the adrenal cortex, where it is incorporated into the steroid synthesis pathway. Due to its structural similarity to cholesterol, adosterol is processed by the adrenal glands in a manner similar to natural cholesterol. The radioactive iodine label allows for the visualization of adrenal gland activity through imaging techniques.

Clinical applications

Adosterol scintigraphy is used in the evaluation of adrenal gland disorders. It helps in:

• Diagnosing primary aldosteronism (Conn's syndrome) by identifying hyperfunctioning adrenal tissue.
• Evaluating Cushing's syndrome to differentiate between adrenal and pituitary causes.
• Assessing adrenal hyperplasia and adrenal adenomas.

Procedure

The procedure involves the intravenous administration of adosterol, followed by imaging at specific intervals to assess the uptake and distribution of the radiotracer in the adrenal glands. The images obtained can help in identifying abnormal adrenal tissue and guide further diagnostic or therapeutic interventions.

Safety and precautions

As with any procedure involving radioactive materials, there are safety considerations to minimize radiation exposure to the patient and healthcare providers. The use of adosterol is generally safe when performed by trained professionals, but it is contraindicated in pregnant women due to the potential risk to the fetus.

Related pages

• Cholesterol
• Adrenal gland
• Nuclear medicine
• Radiopharmaceutical

Gallery

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  Structural formula of Adosterol

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  Ball-and-stick model of Adosterol

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  Adosterol chemical structure

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  Adosterol molecule ball-and-stick model