Adrenergic release inhibitor

Adrenergic Release Inhibitor is a class of drugs that function by inhibiting the release of adrenaline and noradrenaline from the adrenergic neuron. These drugs are primarily used in the treatment of hypertension, anxiety disorders, and panic disorders.

Mechanism of Action

Adrenergic release inhibitors work by blocking the release of neurotransmitters adrenaline and noradrenaline from nerve endings. They do this by inhibiting the action of the enzyme tyrosine hydroxylase, which is responsible for the conversion of tyrosine to dopamine, a precursor of adrenaline and noradrenaline. This results in a decrease in the levels of these neurotransmitters, leading to a reduction in the symptoms of conditions such as hypertension and anxiety disorders.

Uses

Adrenergic release inhibitors are used in the treatment of a variety of conditions, including:

• Hypertension: By reducing the levels of adrenaline and noradrenaline, these drugs can help to lower blood pressure.
• Anxiety disorders: These drugs can help to reduce the symptoms of anxiety by decreasing the levels of adrenaline and noradrenaline.
• Panic disorders: Adrenergic release inhibitors can help to reduce the frequency and severity of panic attacks.

Side Effects

Like all drugs, adrenergic release inhibitors can cause side effects. These may include:

• Dizziness
• Fatigue
• Nausea
• Dry mouth
• Constipation

Examples

Examples of adrenergic release inhibitors include:

• Guanethidine
• Reserpine
• Methyldopa

See Also

• Adrenergic receptor
• Adrenergic agonist
• Adrenergic antagonist

References

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