Adrenopause

Adrenopause is a term that refers to the natural decline in the production of adrenal hormones, particularly dehydroepiandrosterone (DHEA) and its sulfate, dehydroepiandrosterone sulfate (DHEAS), that occurs with aging. This process is analogous to the decline in sex hormones production that occurs in the ovaries and testes, known as menopause and andropause, respectively.

Overview

Adrenopause typically begins in the late 30s or early 40s, with DHEA and DHEAS levels gradually decreasing over time. By the age of 70, these levels may be as low as 20% of their peak levels. This decline is thought to contribute to various age-related changes and health problems, including osteoporosis, cardiovascular disease, depression, and cognitive decline.

Symptoms

The symptoms of adrenopause can vary widely and may include fatigue, decreased libido, mood changes, and increased susceptibility to stress and illness. Some individuals may also experience changes in body composition, such as increased body fat and decreased muscle mass.

Diagnosis

Adrenopause is typically diagnosed through a combination of symptom assessment and laboratory testing. Blood tests can measure levels of DHEA and DHEAS, while symptom assessment can help to identify any changes that may be related to declining adrenal hormone levels.

Treatment

Treatment for adrenopause may involve hormone replacement therapy (HRT) with DHEA. This can help to restore hormone levels and alleviate symptoms. However, HRT is not without risks and should be considered carefully in consultation with a healthcare provider.

See also

• Menopause
• Andropause
• Hormone replacement therapy