Adrenorphin

Adrenorphin, also known as Met-enkephalin-Arg-Phe, is an endogenous, potent opioid peptide. It is produced in the adrenal gland after stress or pain. Adrenorphin has a high affinity for mu-opioid receptors, where it acts as an agonist.

Structure and Function

Adrenorphin is a heptapeptide, meaning it is composed of seven amino acids. Its sequence is Met-Enk-Arg-Phe, which is short for Methionine-Enkephalin-Arginine-Phenylalanine.

The peptide is involved in the body's response to stress and pain. It is released from the adrenal gland in response to these stimuli, and then binds to mu-opioid receptors in the brain. This binding triggers a cascade of events that ultimately leads to the reduction of pain perception.

Clinical Significance

Due to its potent opioid activity, adrenorphin has been studied for its potential use in pain management. However, its use is limited by its short half-life and the risk of developing tolerance and dependence.

See Also

• Opioid peptide
• Adrenal gland
• Mu opioid receptor

References

Adrenorphin Resources
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