Adult Progeria
Adult Progeria -
Adult Progeria - pronunciation[edit source]
(uh-DULT proh-JEER-ee-uh) rare inherited disorder characterized by rapid aging beginning in early adolescence or young adulthood and associated with an increased risk of cancer. Signs and symptoms include being shorter than average, thinning and graying hair, skin changes, thin arms and legs, voice changes, and unusual facial features. This disorder can also lead to health problems such as cataracts, skin ulcers, severe hardening of the arteries, diabetes, osteoporosis and fertility problems. People with adult progeria have an increased risk of cancer, particularly thyroid cancer, skin cancer, and sarcoma (a type of bone or soft tissue cancer). Adult progeria is caused by a mutation (change) in the WRN gene, which makes a protein involved in DNA repair. Also called Werner syndrome and WS.
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Contributors: Prab R. Tumpati, MD
