Ajmaline

Ajmaline is a class Ia antiarrhythmic agent often used in the diagnosis of Brugada syndrome, a rare genetic disorder that can cause heart rhythm problems. It is an alkaloid that is found in the plants of the Apocynaceae family, particularly those in the Rauwolfia genus.

History

Ajmaline was first isolated in 1931 by Salimuzzaman Siddiqui, a Pakistani organic chemist. He named it after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia.

Medical Uses

Ajmaline is used in the diagnosis of Brugada syndrome, a condition that results in a disruption of the heart's normal rhythm. This is done through an ajmaline challenge, where the drug is administered and the patient's ECG is monitored for changes.

Pharmacology

Ajmaline works by blocking the fast inward sodium current (INa). It slows the conduction velocity and increases the duration of the action potential.

Side Effects

Common side effects of ajmaline include nausea, vomiting, and diarrhea. More serious side effects can include heart block, arrhythmias, and hypotension.

See Also

• Antiarrhythmic agent
• Brugada syndrome
• Rauwolfia

References

Ajmaline Resources
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