Akuammine

Akuammine is an indole alkaloid. It is highly prevalent in the seeds of the Picralima nitida tree. Akuammine is related to both yohimbine and mitragynine, both of which are alkaloid plant products with pharmacological properties.

Chemistry

Akuammine, an indole alkaloid, is the most abundant active alkaloid found in the seeds from the tree Picralima nitida, commonly known as the akuamma tree. It bears a structural similarity to both yohimbine and mitragynine, which are also indole alkaloids.

Pharmacology

The pharmacological properties of akuammine are believed to be primarily due to its activity as an opioid receptor agonist. Similar to other opioids, it has analgesic effects, which may occur due to its activity at the μ-opioid receptor.

Uses

Traditionally, the seeds of the Picralima nitida tree, which contain akuammine, have been used in folk medicine in certain regions of Africa as a treatment for various ailments. The seeds are often ground up into a powder, which can be ingested. The akuammine alkaloid itself has been isolated and used in experimental research settings, but is not commonly used in clinical practice.

Safety

As an opioid receptor agonist, akuammine has the potential for abuse and the development of dependence. It may also have side effects similar to other opioids, which can include constipation, nausea, and respiratory depression.

See also

• Picralima nitida
• Indole alkaloids
• Opioid receptor

Akuammine Resources
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