Alclometasone dipropionate

Alclometasone dipropionate is a synthetic corticosteroid used in the treatment of various skin conditions. It is a derivative of prednisolone, and has anti-inflammatory, antipruritic, and vasoconstrictive properties.

Pharmacology

Alclometasone dipropionate acts by binding to the glucocorticoid receptor, leading to changes in gene expression. This results in a decrease in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes, thereby reducing inflammation and itching.

Uses

Alclometasone dipropionate is used topically to treat a variety of skin conditions, including eczema, psoriasis, and contact dermatitis. It is also used to relieve the symptoms of allergic reactions on the skin.

Side effects

Possible side effects of alclometasone dipropionate include skin irritation, burning, and dryness. Long-term use can lead to skin thinning and discoloration. Systemic absorption can result in Cushing's syndrome, hyperglycemia, and glucosuria.

Contraindications

Alclometasone dipropionate is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should not be used on the face, underarms, or groin area unless directed by a physician.

See also

• Corticosteroid
• Topical steroid
• Dermatology