Alcohol dehydrogenase, iron containing 1

Alcohol dehydrogenase, iron containing 1 (also known as ADHFE1) is a protein that in humans is encoded by the ADHFE1 gene. This protein is part of the alcohol dehydrogenase family of proteins, which metabolize a wide variety of substrates, including lipids, retinol, ethanol, and other small molecules.

Function

ADHFE1 is an enzyme that catalyzes the chemical reaction of an alcohol into an aldehyde or ketone by removing a hydrogen atom. This process is known as oxidation. The enzyme is iron-dependent, meaning it requires iron to function properly.

Structure

The ADHFE1 protein is composed of 548 amino acids and has a molecular weight of approximately 60 kDa. The protein structure includes a catalytic domain and an iron-binding domain, which is essential for its enzymatic activity.

Clinical significance

Mutations in the ADHFE1 gene have been associated with hyperglycinemia, a rare metabolic disorder characterized by high levels of glycine in the body.

See also

• Alcohol dehydrogenase
• Enzyme
• Gene
• Protein
• Hyperglycinemia

References

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