Aleglitazar
Aleglitazar[edit | edit source]
Aleglitazar is a pharmaceutical drug that was developed as a dual peroxisome proliferator-activated receptor (PPAR) agonist, targeting both the PPAR_ and PPAR_ subtypes. It was investigated for its potential use in the treatment of type 2 diabetes mellitus and associated cardiovascular disease.
Mechanism of Action[edit | edit source]
Aleglitazar functions by activating the PPAR_ and PPAR_ receptors, which play key roles in the regulation of lipid metabolism and glucose homeostasis. Activation of PPAR_ leads to increased fatty acid oxidation and improved lipid profile, while PPAR_ activation enhances insulin sensitivity and glucose uptake in adipose tissue.
Development and Clinical Trials[edit | edit source]
Aleglitazar was developed by Hoffmann-La Roche and underwent several phases of clinical trials. The drug showed promise in early studies by improving glycemic control and lipid parameters in patients with type 2 diabetes. However, later-stage trials raised concerns about its safety profile, particularly regarding heart failure and renal impairment.
Safety and Efficacy[edit | edit source]
The safety concerns observed in clinical trials included an increased risk of congestive heart failure, bone fractures, and renal dysfunction. These adverse effects led to the discontinuation of its development for the treatment of type 2 diabetes.
Conclusion[edit | edit source]
Despite its initial promise as a dual PPAR agonist, Aleglitazar's development was halted due to safety concerns. The case of Aleglitazar highlights the challenges in developing drugs that target multiple pathways and the importance of thorough safety evaluations in the drug development process.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
