Alfaxalone

Alfaxalone (also known as Alphaxalone) is a neuroactive steroid and general anesthetic. It is used in veterinary medicine for the induction and maintenance of general anesthesia in dogs and cats.

Pharmacology[edit | edit source]

Alfaxalone acts as a positive allosteric modulator at the GABA_A receptor, enhancing the effects of the neurotransmitter GABA and causing sedation, hypnosis, and anesthesia. It has similar effects to other general anesthetics such as propofol and barbiturates.

Medical uses[edit | edit source]

Alfaxalone is used in veterinary medicine for the induction and maintenance of general anesthesia in dogs and cats. It is administered intravenously and has a rapid onset of action. The duration of anesthesia is relatively short, typically lasting around 30 minutes.

Side effects[edit | edit source]

Possible side effects of alfaxalone include respiratory depression, hypotension, and bradycardia. These effects are generally mild and transient. Other potential side effects include muscle twitching, vomiting, and hypersensitivity reactions.

History[edit | edit source]

Alfaxalone was first synthesized in the 1970s and was initially marketed as a mixture with alphadolone under the brand name Saffan. However, this formulation was withdrawn from the market due to issues with histamine release and hypersensitivity reactions. A new formulation of alfaxalone, marketed under the brand name Alfaxan, was introduced in the 2000s.

References[edit | edit source]

External links[edit | edit source]

Alfaxan CD RTU - Drugs.com

Alfaxalone Resources
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