Alloin

Alloin is a compound found in the aloe vera plant, specifically in the plant's latex. It is a type of anthraquinone, a class of compounds known for their laxative effects. Alloin is responsible for the laxative properties of aloe vera.

Chemical Structure and Properties

Alloin is a yellowish, crystalline substance. Its chemical formula is C_{21}H_{22}O_{9}, and it has a molecular weight of 418.39 g/mol. The compound is soluble in ethanol and dimethyl sulfoxide (DMSO), but it is insoluble in water.

Biological Effects

Alloin works as a stimulant laxative, increasing intestinal water content, stimulating mucus secretion, and increasing intestinal peristalsis, contractions that move material through the bowel. These effects can help to alleviate constipation.

However, the use of alloin as a laxative has been associated with several side effects, including abdominal pain and cramps, diarrhea, and electrolyte imbalance. Long-term use can lead to dependence and potential damage to the colon.

Regulation

Due to its potential side effects, the use of alloin in over-the-counter laxatives has been restricted in many countries. In the United States, the Food and Drug Administration (FDA) banned the use of alloin in over-the-counter laxatives in 2002.

See Also

• Aloe vera
• Anthraquinone
• Laxative
• Constipation
• Food and Drug Administration