Alpha-1-acid glycoprotein
Alpha-1-acid glycoprotein (AGP), also known as orosomucoid, is a plasma protein that is primarily synthesized in the liver. It is an acute-phase protein, meaning its levels in the blood increase in response to inflammation.
Structure[edit | edit source]
Alpha-1-acid glycoprotein is a glycoprotein with a high carbohydrate content, which contributes to its negative charge at physiological pH. The protein has a molecular weight of approximately 41-43 kDa and consists of a single polypeptide chain.
Function[edit | edit source]
AGP plays a role in modulating the immune response and acts as a carrier protein for various endogenous and exogenous compounds, including hormones, drugs, and steroids. It binds to lipophilic substances and can affect their bioavailability and pharmacokinetics.
Clinical Significance[edit | edit source]
The levels of alpha-1-acid glycoprotein can be elevated in various conditions, such as infections, trauma, surgery, and cancer. It is often used as a biomarker for inflammatory diseases and can influence the pharmacodynamics of drugs that bind to it.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
- [Alpha-1-acid glycoprotein at UniProt](https://www.uniprot.org/uniprot/P02763)
- [Alpha-1-acid glycoprotein at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=ORM1)
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