Alpha-L-fucosyltransferase

Alpha-L-fucosyltransferase is an enzyme that catalyzes the transfer of fucose residues to N-linked type complex glycoproteins. This enzyme plays a crucial role in the synthesis of glycan structures, which are essential components of many biological systems, including the immune system, cell adhesion, and signal transduction.

Function

Alpha-L-fucosyltransferase is responsible for the addition of fucose to the N-acetylglucosamine residue of glycoproteins. This process is known as fucosylation, and it is a type of glycosylation that is critical for the function of many proteins. Fucosylation can affect protein stability, trafficking, and interactions with other molecules.

Structure

The structure of alpha-L-fucosyltransferase is complex, with multiple domains that contribute to its function. The enzyme contains a catalytic domain, which is responsible for the transfer of fucose, and a substrate-binding domain, which recognizes and binds to the glycoprotein substrate.

Clinical significance

Abnormalities in the function of alpha-L-fucosyltransferase can lead to a variety of diseases. For example, defects in fucosylation can result in congenital disorders of glycosylation, a group of rare genetic disorders that affect a person's ability to produce properly glycosylated proteins. Additionally, changes in the levels of fucosylation have been associated with cancer, inflammatory diseases, and infectious diseases.

File:Alpha-L-fucosyltransferase.png

Structure of Alpha-L-fucosyltransferase

See also

• Fucose
• Glycosylation
• Congenital disorders of glycosylation

References

‎

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian