Alpha-N-acetyl-D-glucosaminidase
Alpha-N-acetyl-D-glucosaminidase is believed to be deficient in Sanfilippo syndrome type B
Alpha-N-acetyl-D-glucosaminidase[edit | edit source]
Alpha-N-acetyl-D-glucosaminidase (often referred to as NAG) is an enzyme that hydrolyzes the terminal alpha-N-acetylgalactosamine or alpha-N-acetylglucosamine residues from glycoproteins, glycolipids, and oligosaccharides.
Function[edit | edit source]
NAG plays an essential role in:
- The degradation and recycling of glycoproteins and glycolipids.
- The catabolism of intracellular bioactive peptides.
Clinical Significance[edit | edit source]
- Increased levels of NAG in urine can be an early marker of kidney tubular damage or dysfunction. It is especially valuable as a marker for acute kidney injury.
- Elevated urinary NAG activity has been observed in various renal disorders, including glomerulonephritis, diabetic nephropathy, and renal tubular acidosis.
Assay Methods[edit | edit source]
- Fluorometric and colorimetric assays are standard methods used for measuring NAG activity in clinical samples.
References[edit | edit source]
- "Urinary N-acetyl-beta-D-glucosaminidase activity and kidney injury molecule-1 as indicators of injury and prognosis of acute kidney injury: a systematic review and meta-analysis." - American Journal of Kidney Diseases.
- "Role of N-acetyl-beta-D-glucosaminidase in the diagnosis and monitoring of diabetic nephropathy" - Journal of Diabetes and its Complications.
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