Alpha-Propiolactone

Alpha-Propiolactone (APL) is a clear, colorless liquid with a slightly sweet odor. It is a synthetic compound that is used primarily as a chemical intermediate in the production of numerous chemicals. It is also used as a sterilant for biological materials and as a laboratory reagent.

Chemical Properties

Alpha-Propiolactone is a cyclic ester (a lactone) with the molecular formula C3H4O2. It is a member of the class of compounds known as propionates. It is a highly reactive compound that can undergo a variety of chemical reactions, including polymerization, hydrolysis, and reaction with nucleophiles.

Uses

Alpha-Propiolactone is used primarily as a chemical intermediate in the production of numerous chemicals. It is also used as a sterilant for biological materials, such as vaccines and blood plasma, and as a laboratory reagent. In the past, it was used as a soil fumigant and as a preservative for certain types of food and beverages, but these uses have been discontinued due to safety concerns.

Health Effects

Exposure to Alpha-Propiolactone can cause irritation to the eyes, skin, and respiratory tract. It is also a potential carcinogen, as it has been shown to cause tumors in laboratory animals. The International Agency for Research on Cancer (IARC) has classified Alpha-Propiolactone as a Group 2B carcinogen, meaning it is possibly carcinogenic to humans.

Safety and Handling

Due to its reactivity and potential health effects, Alpha-Propiolactone should be handled with care. It should be stored in a cool, dry, well-ventilated area away from sources of ignition. Protective clothing, including gloves and eye protection, should be worn when handling this compound.

See Also

• Propionates
• International Agency for Research on Cancer
• Carcinogen