Alpha-Pyrrolidinoheptaphenone

Alpha-Pyrrolidinoheptaphenone (α-Pyrrolidinoheptaphenone, α-PHP, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s which has been reported as a novel designer drug. It is closely related to compounds such as alpha-PVP (flakka) and MDPV (methylenedioxypyrovalerone), sharing a core chemical structure of pyrrolidine-based cathinones. This compound exhibits stimulant and possibly entactogenic effects similar to those of other drugs in its class.

Chemistry

Alpha-Pyrrolidinoheptaphenone is a synthetic compound that belongs to the subclass of cathinones. Cathinones are structurally similar to amphetamines, differing primarily by the presence of a β-keto group on the side chain. The chemical formula for α-PHP is C16H23NO, indicating the presence of a pyrrolidine ring—a characteristic feature of this class of compounds.

Pharmacology

The pharmacological action of α-PHP, like other synthetic cathinones, is primarily characterized by its function as a central nervous system stimulant. It is believed to act by increasing the release of neurotransmitters such as dopamine and norepinephrine while inhibiting their reuptake. This action results in increased levels of these neurotransmitters in the brain, leading to heightened alertness, energy, and euphoria, but also potential for addiction and adverse effects.

Effects

Users of α-PHP may experience a range of effects, both positive and negative. Positive effects can include increased energy, euphoria, enhanced sociability, and increased libido. However, negative effects are also common and can include paranoia, anxiety, agitation, and the potential for psychotic episodes. The risk of adverse effects increases with higher doses and prolonged use.

Legal Status

The legal status of α-PHP varies by country but it has been increasingly controlled or banned in many jurisdictions due to concerns over its potential for abuse, addiction, and harm to public health. In some countries, it is classified as a controlled substance, making its manufacture, distribution, and possession illegal.

Health Risks

The health risks associated with α-PHP are similar to those of other synthetic cathinones and can include cardiovascular issues, such as increased heart rate and blood pressure, as well as neurological effects like seizures and neurotoxicity. There is also a risk of psychological dependence and addiction.

See Also

• Cathinone
• Amphetamine
• Methylenedioxypyrovalerone (MDPV)
• Alpha-PVP