Alpha-glucosidase

Alpha-glucosidase is an enzyme that hydrolyzes terminal, non-reducing alpha-1,4-glucose residues with the release of alpha-glucose. This is a key enzyme in carbohydrate metabolism and its role is critical in the digestion of starch and glycogen.

Function

Alpha-glucosidase breaks down monosaccharides and disaccharides into glucose. This process takes place in the small intestine. The glucose is then absorbed into the bloodstream, where it is used by the body's cells for energy.

Inhibitors

Alpha-glucosidase inhibitors are used to treat type 2 diabetes. These drugs slow the body's breakdown of sugars and carbohydrates, giving the body more time to absorb sugar into the bloodstream. This helps to prevent a rapid rise in blood sugar levels after meals.

Clinical significance

Mutations in the alpha-glucosidase gene can lead to Pompe disease, a disorder characterized by the buildup of glycogen in certain organs and tissues, especially muscles, impairing their ability to function normally.

See also

• Glycogen storage disease
• Carbohydrate metabolism
• Enzyme
• Alpha-glucosidase inhibitors
• Pompe disease

Alpha-glucosidase Resources
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