Alpha-methylhistamine

Alpha-methylhistamine (α-Methylhistamine) is a histamine derivative that acts as a selective agonist at the histamine H3 receptor. It is used in scientific research to investigate the function of this receptor.

Chemistry

Alpha-methylhistamine is a derivative of histamine, a biogenic amine that is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. The alpha-methylhistamine molecule is structurally similar to histamine, with the addition of a methyl group at the alpha position.

Pharmacology

Alpha-methylhistamine acts as a selective agonist at the histamine H3 receptor. This receptor is found in the central nervous system and peripheral nervous system, and is involved in a variety of functions including the regulation of neurotransmitter release, sleep-wake cycle, and cognitive function.

Research Use

In scientific research, alpha-methylhistamine is used to investigate the function of the histamine H3 receptor. It can be used in in vitro studies to activate the receptor, or in in vivo studies to investigate the effects of receptor activation on behavior and physiological function.

See Also

• Histamine
• Histamine H3 receptor
• Agonist
• Neurotransmitter

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