Altrenogest

Altrenogest (or allyltrenbolone) is a progestin of the 19-nortestosterone group which is widely used in veterinary medicine to suppress or synchronize estrous in horses and pigs. It is available for veterinary use in both Europe and the United States.

Pharmacology

Altrenogest is a synthetic trienic C21 progestin that is an analogue of allyl trenbolone. It is a progestogen that is related to the naturally occurring steroid hormone, progesterone. Altrenogest is different from other synthetic progestogens in that it is orally active and is practically non-toxic.

Uses

Altrenogest is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug. It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. One group of authors (Squires et al., 1983) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more are also considered to be excellent candidates for progestin treatment.

Side Effects

Altrenogest is very safe to use. However, it may cause mild colic, urticaria, or salivation. These side effects are rare and are usually associated with the oral administration of the drug.

See Also

• Progestin
• 19-nortestosterone
• Estrous
• Progesterone

References

Altrenogest Resources
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