Amadinone acetate
Amadinone acetate is a synthetic, steroidal progestin that was never marketed. It is a derivative of progesterone and was synthesized in the late 1960s. Despite its synthesis and identification, amadinone acetate has not been extensively studied, and its potential uses and effects are not well-documented in the scientific literature.
Chemistry[edit | edit source]
Amadinone acetate, also known as 17α-acetoxy-6-dehydroprogesterone, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone and is a member of the class of compounds known as pregnanes.
Synthesis[edit | edit source]
The synthesis of amadinone acetate was first reported in 1969 by scientists at the pharmaceutical company Hoechst AG. The synthesis involves the acetylation of 17α-hydroxyprogesterone.
Pharmacology[edit | edit source]
As a progestin, amadinone acetate has progestogenic activity. It binds to and activates the progesterone receptor, a nuclear receptor that plays a critical role in the regulation of the menstrual cycle, pregnancy, and embryogenesis.
Potential Uses[edit | edit source]
Due to its progestogenic activity, amadinone acetate could potentially be used in hormonal contraception or hormone replacement therapy, although it has never been marketed for these or any other uses.
See Also[edit | edit source]
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