Amadinone acetate

Amadinone Acetate

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Chemical structure of Amadinone Acetate

Amadinone acetate is a synthetic progestin, a type of hormone used in hormonal contraception and hormone replacement therapy. It is a derivative of 19-nortestosterone and is known for its potent progestogenic activity.

Chemical Properties

Amadinone acetate is a steroid with the chemical formula C23H29NO3. It is characterized by its acetate ester, which enhances its bioavailability and pharmacokinetics. The compound is typically administered orally.

Mechanism of Action

As a progestin, amadinone acetate works by binding to the progesterone receptors in the body. This binding leads to changes in the endometrium, making it less suitable for implantation of a fertilized ovum. It also thickens the cervical mucus, which acts as a barrier to spermatozoa.

Clinical Uses

Amadinone acetate is primarily used in contraceptive formulations. It is often combined with an estrogen to form a combined oral contraceptive pill. Additionally, it may be used in hormone replacement therapy for menopausal symptoms and in the treatment of certain gynecological disorders.

Side Effects

Common side effects of amadinone acetate include nausea, headache, breast tenderness, and mood changes. Long-term use may be associated with an increased risk of thromboembolism and breast cancer.

Pharmacokinetics

Amadinone acetate is well absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. It is metabolized primarily by the cytochrome P450 enzyme system and is excreted in the urine and feces.

Related Pages

• Progestin
• Hormonal contraception
• Hormone replacement therapy
• 19-nortestosterone