Ambroxide

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Ambroxide


Ambroxide, also known as Ambroxan, is a synthetic organic compound used primarily as a fragrance in the perfumery industry. It is derived from sclareol, a natural compound found in the clary sage plant (Salvia sclarea). Ambroxide is valued for its long-lasting, warm, woody, and ambergris-like aroma, making it a popular choice in the formulation of a wide range of perfumes and scented products.

History[edit | edit source]

The use of ambergris, a natural secretion from the sperm whale, has a long history in perfumery due to its unique scent and fixative properties. However, due to ethical, legal, and sustainability concerns surrounding the use of natural ambergris, chemists sought synthetic alternatives. Ambroxide was developed as a synthetic substitute, offering a similar olfactory profile without the need to rely on animal-derived ingredients.

Chemical Properties[edit | edit source]

Ambroxide belongs to the family of terpenes and is a macrocyclic musk compound. Its chemical formula is C16H28O. The compound is known for its excellent fixative properties, meaning it can help stabilize the volatility of other fragrance components, thereby extending the longevity of a scent on the skin or in the air.

Production[edit | edit source]

The production of Ambroxide involves the chemical synthesis from sclareol, which is extracted from the clary sage plant. The process typically involves several steps, including the hydrogenation of sclareol to produce sclareolide, followed by a series of chemical reactions that ultimately yield Ambroxide.

Applications[edit | edit source]

Ambroxide is widely used in the creation of perfumes, colognes, and other scented products. Its ability to mimic the complex scent of ambergris, along with its fixative properties, makes it a valuable ingredient in the fragrance industry. Additionally, Ambroxide is used in some cosmetics and personal care products for its scent-enhancing qualities.

Safety and Regulation[edit | edit source]

The safety of Ambroxide has been evaluated by various regulatory bodies, including the International Fragrance Association (IFRA), which sets guidelines for the safe use of fragrance ingredients. Ambroxide is generally considered safe for use in perfumery and cosmetics, provided it is used within the recommended concentration limits.

Environmental Impact[edit | edit source]

As a synthetic alternative to natural ambergris, Ambroxide offers a more sustainable and ethical option for the fragrance industry. Its production does not involve the harm of marine life, and it provides a consistent quality and supply, unlike the variable availability of natural ambergris.


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Contributors: Prab R. Tumpati, MD