Ambroxol
Structural formula of Ambroxol
Ball-and-stick model of Ambroxol
Antbron 15mg by Towa Pharmaceutical
Ambroxol[edit | edit source]
Ambroxol is a mucolytic agent used in the treatment of respiratory diseases associated with viscous or excessive mucus. It is commonly used to alleviate symptoms of cough and chronic obstructive pulmonary disease (COPD).
Pharmacology[edit | edit source]
Ambroxol works by breaking down mucopolysaccharides in the mucus, thereby reducing its viscosity and facilitating its clearance from the respiratory tract. It enhances the production of surfactant, a substance that helps keep the alveoli open, improving lung function.
Mechanism of Action[edit | edit source]
Ambroxol acts on the serous cells of the respiratory tract to increase the production of thin, watery secretions. This action helps to dilute the mucus, making it less sticky and easier to expel through coughing. Additionally, ambroxol has been shown to have anti-inflammatory and antioxidant properties, which may contribute to its therapeutic effects.
Clinical Uses[edit | edit source]
Ambroxol is indicated for use in conditions where there is excessive or thickened mucus, such as:
It is also used as an adjunct therapy in the management of acute respiratory distress syndrome (ARDS).
Dosage and Administration[edit | edit source]
Ambroxol is available in various forms, including tablets, syrups, and inhalation solutions. The dosage and administration depend on the age of the patient and the severity of the condition. It is important to follow the prescribed dosage to avoid potential side effects.
Side Effects[edit | edit source]
Common side effects of ambroxol include:
- Gastrointestinal disturbances such as nausea and vomiting
- Allergic reactions like rash and urticaria
- Headache
Severe side effects are rare but may include anaphylactic reactions and Stevens-Johnson syndrome.
Contraindications[edit | edit source]
Ambroxol is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with peptic ulcer disease and those with a history of gastrointestinal bleeding.
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