Aminoacyltransferase

Aminoacyltransferase is an enzyme that plays a crucial role in the process of protein synthesis. It is responsible for the attachment of an amino acid to its corresponding transfer RNA (tRNA), a process known as aminoacylation or tRNA charging. This process is essential for the translation of genetic code into proteins.

Function

Aminoacyltransferase catalyzes the esterification of a specific amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA. This process occurs in two steps:

1. The amino acid is first activated by ATP to form an aminoacyl-adenylate.
2. The enzyme then transfers the amino acid to the tRNA, forming an aminoacyl-tRNA.

This reaction ensures that the correct amino acid is added to the growing polypeptide chain during protein synthesis.

Structure

Aminoacyltransferases are typically composed of multiple subunits and have a complex three-dimensional structure. The active site of the enzyme, where the aminoacylation reaction takes place, is usually located in a cleft between the subunits.

Clinical significance

Mutations in the genes encoding aminoacyltransferases can lead to a variety of diseases. For example, defects in the enzyme alanyl-tRNA synthetase can cause neurological disorders such as Charcot-Marie-Tooth disease.

See also

• Transfer RNA
• Protein synthesis
• Amino acid
• Enzyme

References

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