Aminoguanidine
Aminoguanidine also known as Pimagedine is a diamondoid and an inhibitor of the enzyme Nitric Oxide Synthase. It is a drug that is used for the treatment of diabetic nephropathy, a complication of diabetes that affects the kidneys.
Chemistry[edit | edit source]
Aminoguanidine is a hydrazine derivative and has the chemical formula C2H8N4. It is a white crystalline powder that is soluble in water and slightly soluble in ethanol. It has a pKa of 5.3 and a melting point of 102-104 degrees Celsius.
Pharmacology[edit | edit source]
Aminoguanidine inhibits the formation of Advanced Glycation End-products (AGEs) by reacting with 3-deoxyglucosone. AGEs are proteins or lipids that become glycated after exposure to sugars. They are implicated in various diseases such as diabetes, aging, and chronic renal failure.
Clinical Use[edit | edit source]
Aminoguanidine is used in the treatment of diabetic nephropathy. It has been shown to reduce the progression of renal disease in patients with type 1 diabetes and microalbuminuria. However, its use is limited due to its side effects which include gastrointestinal disturbances, anemia, and liver toxicity.
Research[edit | edit source]
Research is ongoing to develop new drugs based on the aminoguanidine molecule that have fewer side effects and are more effective in treating diabetic nephropathy.
See Also[edit | edit source]
References[edit | edit source]
Aminoguanidine Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD