Aminosuccinic acid

Aminosuccinic Acid also known as Aspartic Acid is an amino acid that plays a crucial role in the metabolism of living organisms. It is non-essential in humans, meaning the body can synthesize it as needed.

Chemistry

Aminosuccinic Acid is an α-amino acid that contains a carboxylate (acidic) functional group and an amino (basic) functional group. Its chemical formula is HOOCCH(NH2)CH2COOH. It exists in two forms or isomers, L- and D-aspartic acid, with L-aspartic acid being the form that participates in the biosynthesis of proteins.

Biological Role

In humans and other animals, aminosuccinic acid is a non-essential amino acid, meaning it can be synthesized from central metabolic pathway intermediates and is not required in the diet. It is one of the building blocks of proteins and also serves as a neurotransmitter.

Metabolic Pathways

Aminosuccinic Acid is produced in the body through the transamination of the Krebs cycle intermediate oxaloacetate. The enzyme aspartate transaminase catalyzes this reaction, which also produces glutamate. Aminosuccinic Acid can also be converted back into oxaloacetate, allowing it to enter the Krebs cycle and be used for energy production.

Health Implications

Aminosuccinic Acid is generally considered safe and is used as a component of parenteral and enteral nutrition. However, high levels of this amino acid have been associated with certain neurological disorders, including Alzheimer's disease and depression.

See Also

• Amino Acid
• Metabolism
• Krebs Cycle
• Alzheimer's disease
• Depression

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