Thioacetazone

From WikiMD.com Medical Encyclopedia

(Redirected from Amithiozone)

Antitubercular medication


Thioacetazone
Thioacetazone.svg
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG


Thioacetazone is an antibacterial medication primarily used in the treatment of tuberculosis (TB). It is known for its role in combination therapy for Mycobacterium tuberculosis, the bacterium responsible for TB. Thioacetazone is particularly noted for its use in resource-limited settings due to its cost-effectiveness.

Chemical Structure[edit | edit source]

Chemical structure of Thioacetazone

Thioacetazone is a thiosemicarbazone derivative, characterized by its sulfur-containing moiety. The chemical structure of thioacetazone includes a thiosemicarbazone group attached to an aromatic ring, which is crucial for its antibacterial activity.

Mechanism of Action[edit | edit source]

Thioacetazone works by inhibiting the synthesis of mycolic acids, essential components of the mycobacterial cell wall. This inhibition disrupts the integrity of the cell wall, leading to the death of the bacterium. The drug is bacteriostatic, meaning it inhibits the growth and reproduction of bacteria rather than killing them directly.

Clinical Use[edit | edit source]

Thioacetazone is used in combination with other antitubercular drugs such as isoniazid and rifampicin. It is particularly useful in the treatment of drug-resistant TB strains. However, its use has declined in many parts of the world due to the availability of more effective and less toxic alternatives.

Side Effects[edit | edit source]

The use of thioacetazone is associated with several side effects, the most significant being skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. These severe skin reactions are more common in patients with HIV/AIDS, which has led to caution in its use among these populations.

History[edit | edit source]

Thioacetazone was first introduced in the 1940s as a treatment for tuberculosis. It gained popularity due to its low cost and effectiveness in combination therapy. However, the emergence of severe side effects and the development of more effective drugs have limited its use in modern TB treatment regimens.

Related Pages[edit | edit source]

See Also[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD