Andecaliximab
Human monoclonal antibody
Overview[edit | edit source]
Andecaliximab is a monoclonal antibody that has been investigated for its potential use in the treatment of various diseases, including cancer and inflammatory diseases. It is specifically designed to target and inhibit the activity of matrix metalloproteinase 9 (MMP-9), an enzyme involved in the breakdown of the extracellular matrix and implicated in various pathological processes.
Mechanism of Action[edit | edit source]
Andecaliximab functions by binding to MMP-9, thereby inhibiting its enzymatic activity. MMP-9 is known to play a role in the degradation of the extracellular matrix, which is a critical process in tumor invasion and metastasis, as well as in inflammation. By inhibiting MMP-9, andecaliximab may help to prevent the progression of tumors and reduce inflammation.
Clinical Development[edit | edit source]
Andecaliximab has been evaluated in clinical trials for its efficacy and safety in treating various conditions. It has been studied in combination with other therapeutic agents, such as chemotherapy drugs, to assess its potential to enhance treatment outcomes.
Cancer[edit | edit source]
In the context of cancer, andecaliximab has been investigated for its ability to inhibit tumor growth and metastasis. Clinical trials have explored its use in combination with standard chemotherapy regimens in patients with advanced solid tumors.
Inflammatory Diseases[edit | edit source]
Andecaliximab has also been studied for its potential to treat inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. By targeting MMP-9, it may help to reduce the inflammatory response and tissue damage associated with these conditions.
Safety and Efficacy[edit | edit source]
The safety and efficacy of andecaliximab have been evaluated in several clinical trials. Common side effects observed in these studies include fatigue, nausea, and diarrhea. The overall safety profile of andecaliximab is considered acceptable, with manageable adverse effects.
Future Directions[edit | edit source]
Research on andecaliximab continues to explore its potential applications in various therapeutic areas. Ongoing studies aim to better understand its mechanism of action, optimize dosing regimens, and identify patient populations that may benefit most from its use.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
