Andexanet alfa
Andexanet alfa is a recombinant protein that is used as an antidote to reverse the anticoagulant effects of direct factor Xa inhibitors. It is a modified form of the human Factor X protein.
Etymology[edit | edit source]
The name "andexanet alfa" is derived from "antidote for Xa inhibitors" and "alfa" is a common suffix for recombinant proteins.
Mechanism of action[edit | edit source]
Andexanet alfa works by binding to direct factor Xa inhibitors, preventing them from inhibiting the activity of factor Xa. This allows the normal clotting process to resume.
Uses[edit | edit source]
Andexanet alfa is used to reverse the anticoagulant effects of direct factor Xa inhibitors in patients who are experiencing serious or uncontrolled bleeding or who require urgent surgery.
Side effects[edit | edit source]
Common side effects of andexanet alfa include nausea, vomiting, and headache. Serious side effects can include thrombosis and ischemia.
History[edit | edit source]
Andexanet alfa was approved for medical use in the United States in 2018. It is marketed under the brand name Andexxa by Portola Pharmaceuticals.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
