Andexanet alfa

Andexanet alfa is a recombinant protein that is used as an antidote to reverse the anticoagulant effects of direct factor Xa inhibitors. It is a modified form of the human Factor X protein.

Etymology[edit | edit source]

The name "andexanet alfa" is derived from "antidote for Xa inhibitors" and "alfa" is a common suffix for recombinant proteins.

Mechanism of action[edit | edit source]

Andexanet alfa works by binding to direct factor Xa inhibitors, preventing them from inhibiting the activity of factor Xa. This allows the normal clotting process to resume.

Uses[edit | edit source]

Andexanet alfa is used to reverse the anticoagulant effects of direct factor Xa inhibitors in patients who are experiencing serious or uncontrolled bleeding or who require urgent surgery.

Side effects[edit | edit source]

Common side effects of andexanet alfa include nausea, vomiting, and headache. Serious side effects can include thrombosis and ischemia.

History[edit | edit source]

Andexanet alfa was approved for medical use in the United States in 2018. It is marketed under the brand name Andexxa by Portola Pharmaceuticals.

See also[edit | edit source]

Andexanet alfa Resources
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