Angiolathyrism

Angiolathyrism is a rare medical condition that results from the consumption of certain types of legumes, specifically those from the genus Lathyrus. This condition is characterized by the weakening and paralysis of the lower limbs.

Causes

The primary cause of angiolathyrism is the consumption of the Lathyrus genus of legumes, particularly Lathyrus sativus, also known as grass pea or chickling vetch. These legumes contain a neurotoxic amino acid known as ODAP (β-N-oxalyl-L-α,β-diaminopropionic acid), which is believed to be the primary agent causing the condition.

Symptoms

The symptoms of angiolathyrism typically include weakness and stiffness in the lower limbs, which can progress to paralysis. Other symptoms may include muscle pain, numbness, and difficulty walking. In severe cases, the condition can lead to permanent disability.

Treatment

There is currently no specific treatment for angiolathyrism. Management of the condition primarily involves avoiding consumption of the offending legumes and providing supportive care to manage symptoms.

Prevention

Prevention of angiolathyrism involves avoiding consumption of Lathyrus legumes, particularly in areas where these legumes are a staple food and other food sources are scarce.

See also

• Lathyrism
• Neurotoxicity
• Legumes
• ODAP

References

Angiolathyrism Resources
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