Angiopoietin 2

Angiopoietin 2 (also known as ANGPT2) is a protein that in humans is encoded by the ANGPT2 gene. It is a member of the angiopoietin family and plays a crucial role in the regulation of vascular development and angiogenesis.

Function

ANGPT2 is a naturally occurring antagonist of ANGPT1 that competes for binding with the Tie2 receptor, and functions as a vascular destabilizer. ANGPT2 is upregulated in hypoxic environments and appears to play a crucial role in mediating controlled vascular regression. It is context-dependent and can act as a pro-angiogenic factor under certain conditions.

Clinical significance

Elevated levels of ANGPT2 have been associated with various diseases, including cancer, sepsis, and diabetes. In cancer, ANGPT2 may contribute to tumor angiogenesis and metastasis. In sepsis, it is thought to contribute to the vascular leakage and inflammation associated with the disease. In diabetes, it may contribute to the vascular complications of the disease.

Research

Research into ANGPT2 has focused on its role in disease and its potential as a therapeutic target. Several drugs that target the ANGPT2 pathway are currently in clinical trials for various diseases, including cancer and diabetic retinopathy.

See also

• Angiopoietin
• Tie2
• Angiogenesis